The restaurant celebrated its 125th anniversary in 2013. In connection with that celebration, the restaurant opened a pop-up art gallery next door. The gallery featured original art by New York City artists such as Baron Von Fancy and others.
In popular culture
Katz's was the site of Meg Ryan's famous fake orgasm scene in the 1989 romantic comedy When Harry Met Sally..., followed by Estelle Reiner's iconic line "I'll have what she's having"; the table at which Ryan and Billy Crystal sat is marked with a sign that says, "Where Harry met Sally...hope you have what she had! Enjoy!"
It was the site of Johnny Depp's character meeting with an FBI contact in Donnie Brasco (1997).
Katz's Deli is the site for a scene in Across the Universe (2007), in which one of the main characters reveals he has been drafted into the Vietnam War.
Katz's appears in the movie Enchanted (2007) with Amy Adams and Patrick Dempsey.
- Katz's Delicatessen is featured in the Hardy Boys Casefiles series in the episode titled "Evil, Inc." The place was originally introduced to the Hardys after the "Dead on Target" case as the Gray Man's "...less-than-overwhelming gratitiude for the Hardys' help in foiling the terrorist plot". The place is supposed to be a secret meeting place for the Gray Man and his agents, although the Hardys suspect that "Katz's great corned beef sandwiches had something to do with the Gray Man's fondness for the place".
- Law & Order has filmed outside the restaurant.
- Impractical Jokers filmed for a season 4 episode inside the restaurant, as did Man vs. Food.